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MonastrolCat. No. 1305 |
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Chemical Name: 1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester |
Biological Activity
Potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50 = 14 μM).Licensing Information
Sold with the permission of Harvard UniversityCertificate of Analysis / Safety Data Sheet
References
Mayer et al (1999) Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286 971. PMID: 10542155.
Kapoor et al (2000) Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J.Cell Biol. 150 975. PMID: 10973989.
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Keywords: Monastrol, supplier, Selective, inhibitors, mitotic, kinesin, Eg5, Mitosis
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