Home » Pharmacology » Enzymes » Kinases » Checkpoint Kinase » TCS 2312

TCS 2312

Cat. No. 3038

Price and Availability

For TCS 2312 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol

Biological Activity

Potent and selective checkpoint kinase 1 (chk1) inhibitor (K_i = 0.38 nM, EC₅₀ = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.

Technical Data

M.Wt:

412.48

Formula:

C₂₅H₂₄N₄O₂

Solubility:

Soluble to 20 mM in DMSO

Purity:

>97 %

Storage:

Store at -20°C

CAS No:

838823-31-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Teng et al (2007) Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J.Med.Chem. 50 5253. PMID: 17887663.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Cell Cycle Checkpoint Control Kinases

Checkpoint Kinase Kinases

Keywords: TCS 2312, supplier, Potent, Chk1, inhibitors, Checkpoint, Kinases, Control, TCS2312

Quick Order

Find multiple products by catalog number

Cancer Research Guide

Request your free copy

Highlights over 350 products for cancer research. Request a copy or view PDF today.

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

Checkpoint Kinases & the DNA Damage Response

Written by Michelle D. Garrett and Ian Collins

A summary of the response of the checkpoint kinase signaling network to DNA damage, including activation of DNA repair, cell-cycle arrest, senescence and apoptosis.