R&D Systems Inc. Tocris Bioscience Boston Biochem

TCS 2312

Cat. No. 3038

TCS 2312 C25H24N4O2 [838823-31-7]

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Chemical Name: 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol

Biological Activity

Potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.

Technical Data

M.Wt:
412.48
Formula:
C25H24N4O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
838823-31-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Teng et al (2007) Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J.Med.Chem. 50 5253. PMID: 17887663.

If you know of a relevant citation for this product please let us know.

Keywords: TCS 2312, supplier, Potent, Chk1, inhibitors, Checkpoint, Kinases, Control, TCS2312

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