Home » Pharmacology » Enzyme-Linked Receptors » Receptor Tyrosine Kinases (RTKs) » VEGFR » SU 5416

SU 5416

Cat. No. 3037

Price and Availability

For SU 5416 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Semaxinib

Chemical Name: 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one

Biological Activity

Inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Displays no activity against EGFR, HER2, IGF1R and PDGFR. Inhibits tumor vascularization and growth of multiple tumor types.

Technical Data

M.Wt:

238.28

Formula:

C₁₅H₁₄N₂O

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Desiccate at -20°C

CAS No:

204005-46-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Fong et al (1999) SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularisation, and growth of multiple tumor types. Cancer Res. 59 99. PMID: 9892193.

Smolich et al (2001) The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-Kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood 97 1413. PMID: 11222388.

Mologni et al (2006) Inhibition of RET tyrosine kinase by SU5416. J.Mol.Endocrinol. 37 199. PMID: 17032739.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Angiogenesis FLT3 Growth Factor Receptors MET Receptor

Other RTKs Receptor Tyrosine Kinases (RTKs) VEGFR

Keywords: SU 5416, supplier, VEGFR, inhibits, inhibitors, c-kit, KIT, Ret, cMET, FLT3, Hepatocyte, Growth, Factor, Receptors, HGFR, RTK, Receptor, Tyrosine, Kinases, RTKs, Vascular, Endothelial, KDR, SU5416

Quick Order

Find multiple products by catalog number

Cancer Research Guide

Request your free copy

Highlights over 350 products for cancer research. Request a copy or view PDF today.

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.

VEGF Pathway

VEGF signaling regulates vascular development (vasculogenesis) and the formation of new blood vessels (angiogenesis). View pathway or download PDF today.