R&D Systems Inc. Tocris Bioscience Boston Biochem

SD 1008

Cat. No. 3035

SD 1008 C18H19NO5 [960201-81-4]

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Chemical Name: (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester

Biological Activity

JAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Technical Data

M.Wt:
329.35
Formula:
C18H19NO5
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
960201-81-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Duan et al (2007) 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel Janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells. Mol.Pharmacol. 72 1137. PMID: 17675586.

If you know of a relevant citation for this product please let us know.

Keywords: SD 1008, supplier, JAK2, STAT3, signaling, pathway, inhibitors, inhibits, activation, Src, SD1008

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