Cat. No. 3035
Chemical Name: (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylme
Biological ActivityJAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Duan et al (2007) 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel Janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells. Mol.Pharmacol. 72 1137. PMID: 17675586.
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Keywords: SD 1008, supplier, JAK2, STAT3, signaling, pathway, inhibitors, inhibits, activation, Src, SD1008