Cat. No. 3035
Chemical Name: (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylme
Biological ActivityJAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Duan et al (2007) 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel Janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells. Mol.Pharmacol. 72 1137. PMID: 17675586.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SD 1008, supplier, JAK2, STAT3, signaling, pathway, inhibitors, inhibits, activation, Src, SD1008, STAT Inhibitors
Find multiple products by catalog number
New Products in this Area
Stat3 inhibitor; blocks cancer stem cell self-renewalDMXAA
mSTING agonist; induces antitumor immunological responsesC 87
TNF-α inhibitorJTE 607 dihydrochloride
Cytokine release inhibitor; anti-inflammatory
One Day Symposium
January 12, 2016