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Cortistatin-8

Cat. No. 3033

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Alternative Name: CST-8

Biological Activity

Synthetic cortistatin analog that lacks the ability to bind somatostatin receptors but retains ghrelin receptor binding. Acts as a ghrelin receptor antagonist; counteracts the response of ghrelin on gastric acid secretion.

Technical Data

M.Wt:

1009.25

Formula:

C₄₇H₆₈N₁₂O₉S₂

Sequence:

PCFWKTCK

(Modifications: Trp-4 = D-Trp, Disulfide bridge between 2 - 7, Lys-8 = C-terminal amide)

Solubility:

Soluble to 2 mg/ml in 20% acetonitrile

Storage:

Desiccate at -20°C

CAS No:

485803-62-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Luque et al (2006) Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on growth hormone secretion in somatotropes. J.Mol.Endocrinol. 36 547. PMID: 16720722.

Sibilia et al (2006) Evidence for a role of the GHS-R_1a receptors in ghrelin inhibition of gastric acid secretion in the rat. J.Neuroendocrinol. 18 122. PMID: 16420281.

Prodam et al (2008) Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides 42 89. PMID: 18061663.

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Keywords: Cortistatin-8, supplier, Ghrelin, receptor, antagonists, GHS-R1a, Receptors, Growth, Hormone, Secretagogue, 1a, CST8

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