Cat. No. 3033
Alternative Name: CST-8
Biological ActivitySynthetic cortistatin analog that lacks the ability to bind somatostatin receptors but retains ghrelin receptor binding. Acts as a ghrelin receptor antagonist; counteracts the response of ghrelin on gastric acid secretion.
(Modifications: Trp-4 = D-Trp, Disulfide bridge between 2 - 7, Lys-8 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Luque et al (2006) Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on growth hormone secretion in somatotropes. J.Mol.Endocrinol. 36 547. PMID: 16720722.
Sibilia et al (2006) Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat. J.Neuroendocrinol. 18 122. PMID: 16420281.
Prodam et al (2008) Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides 42 89. PMID: 18061663.
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Keywords: Cortistatin-8, supplier, Ghrelin, receptor, antagonists, GHS-R1a, Receptors, Growth, Hormone, Secretagogue, 1a, CST8
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