Cat. No. 0652
Chemical Name: N-(2,6-dioxo-3-piperidinyl)phthalim
Biological ActivityTeratogen, sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Merck Index 12 9390.
Sampaio et al (1991) Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J.Exp.Med. 173 699. PMID: 1997652.
Makonkawkeyoon et al (1993) Thalidomide inhibits the replication of human-immunodeficiency-virus type 1. Proc.Natl.Acad.Sci.U.S.A. 90 5974. PMID: 8327469.
Kanbayashi et al (1996) Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. Neuroreport 7 1881. PMID: 8905685.
Boireau et al (1997) Thalidomide reduces MPTP-induced decrease in striatal dopamine levels in mice. Neurosci.Lett. 234 123. PMID: 9364513.
Zhang et al (2008) Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma. J.Exp.Clin.Cancer Res. 27 60. PMID: 18983651.
If you know of a relevant citation for this product please let us know.
Keywords: Thalidomide, supplier, TNF-α, TNF-alpha, synthesis, inhibitors, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, Signaling, Signalling, teratogen, anti-inflammatory
Find multiple products by catalog number
New Products in this Area
Stat3 inhibitor; blocks cancer stem cell self-renewalDMXAA
mSTING agonist; induces antitumor immunological responsesC 87
TNF-α inhibitorJTE 607 dihydrochloride
Cytokine release inhibitor; anti-inflammatory
One Day Symposium
January 12, 2016