CP 31398 dihydrochloride
Cat. No. 3023
Chemical Name: N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4
Biological Activityp53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Foster et al (1999) Pharmacological rescue of mutant p53 conformation and function. Science 286 2507. PMID: 10617466.
Wischhusen et al (2003) CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene 22 8233. PMID: 14614447.
Demma et al (2004) CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73. J.Biol.Chem. 279 45887. PMID: 15308639.
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