CP 31398 dihydrochloride

Cat No. 3023

CP 31398 dihydrochloride C22H26N4O.2HCl [259199-65-0]

Price and Availability

For CP 31398 dihydrochloride pricing & availability please select your country from the drop down menu:
Submit

Chemical Name: N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N- dimethyl-1,3-propanediamine dihydrochloride

Biological Activity

p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Technical Data

M.Wt:
435.39
Formula:
C22H26N4O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
[259199-65-0]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Foster et al (1999) Pharmacological rescue of mutant p53 conformation and function. Science 286 2507. Wischhusen et al (2003) CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene 22 8233. Demma et al (2004) CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73. J.Biol.Chem. 279 45887.

If you know of a useful citation for this product please let us know.

View Related Products by Target

Keywords: CP 31398 dihydrochloride, p53-stabilizing, p53-stabilising, agent, Transcription, Factors, CP31398, dihydrochloride, Pfizer

Buy Now / Print Quote

Find multiple products by catalog number


divider line

Print Quote Facility

Order via your purchasing department

Print Quote Facility

It's now even easier to place orders via your purchasing department.

Simply add a product to your cart & click on the "Print Quote" button.

more
divider line

Signal Transduction Guide

Signal Transduction Guide

A collection of more than 600 products for signal transduction research. View PDF today.

request
divider line

Cancer Research Guide

Cancer Research Guide

Highlights over 400 products for cancer research. Request a copy or view PDF today.

request
divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.

request
divider line

New Products in this Area

HLI 373

Hdm2 inhibitor; activates p53-dependent transcription

SJ 172550

MDMX inhibitor. Disrupts MDMX-p53 interaction

INH1

Hec1 inhibitor; causes arrest of mitosis

Cyclic Pifithrin-α hydrobromide

p53 inhibitor

Sign-up for new product e-alerts
divider line

RSS News Feed

Find out about new products as soon as they go live!

Get the Tocris RSS feed

Click on the orange RSS button to read more about our RSS feed and actively opt in.

more