CP 31398 dihydrochloride

Cat. No. 3023

CP 31398 dihydrochloride C22H26N4O.2HCl [1217195-61-3]

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Chemical Name: N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride

Biological Activity

p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Foster et al (1999) Pharmacological rescue of mutant p53 conformation and function. Science 286 2507. PMID: 10617466.

Wischhusen et al (2003) CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene 22 8233. PMID: 14614447.

Demma et al (2004) CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73. J.Biol.Chem. 279 45887. PMID: 15308639.

If you know of a relevant citation for this product please let us know.

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