R&D Systems Inc. Tocris Bioscience Boston Biochem

SB 205607 dihydrobromide

Cat. No. 0921

SB 205607 dihydrobromide C23H24N2O.2HBr [148545-09-9]

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Alternative Name: TAN 67

Chemical Name: (R*,S*)-(±)-2-Methyl-4aa-(3-hydroxyp­henyl)-1,2,3,4,4a,5,12,12aa-octahydroquinolino[2,3­,3-g]isoquinoline dihydrobromide

Biological Activity

The first described non-peptide δ1 opioid receptor agonist with very high affinity and selectivity for the δ1 subtype (Ki values are 1.12, 2320 and 1790 nM at δ1, μ and κ receptors respectively).

Licensing Information

Sold under license

Technical Data

M.Wt:
506.28
Formula:
C23H24N2O.2HBr
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at RT
CAS No:
148545-09-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Nagase et al (1994) Syntheses of non-peptidic delta opioid agonists and their structure-activity relationships. Jpn.J.Pharmacol. 64 Suppl. 1, 35P.

Kamei et al (1995) Antinociceptive effects of the selective non-peptidic δ-opioid receptor agonist TAN-67 in diabetic mice. Eur.J.Pharmacol. 276 131. PMID: 7781682.

Knap et al (1995) Properties of TAN-67, a non-peptidic β-opioid receptor agonist, at cloned human δ- and μ-opioid receptors. Eur.J.Pharmacol. 291 129. PMID: 8566162.

Nagase et al (2001) The pharmacological profile of δ opioid receptor ligands (+) and (-) TAN-67 on pain modulation. Life Sci. 68 2227. PMID: 11358331.

If you know of a relevant citation for this product please let us know.

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Keywords: SB 205607 dihydrobromide, supplier, δ1-opioid, delta1-opioid, selective, high, affinity, non-peptide, agonists, DOP, Receptors, OP1, SB205607, dihydrobromide, TAN67

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