SKF 91488 dihydrochloride

Cat. No. 0512

SKF 91488 dihydrochloride C7H17N3S.2HCl [68941-21-9]

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Chemical Name: 4-(N,N-Dimethylamino)butylisothiourea dihydrochloride

Biological Activity

Homolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.

Technical Data

Soluble to 75 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet


Beaven and Shaff (1979) New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 28 183. PMID: 34400.

Beaven and Shaff (1979) Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 9 455. PMID: 161853.

Ohuri et al (1992) Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 261 1268. PMID: 1534842.

Aiello et al (1997) Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 355 354. PMID: 9089666.

If you know of a relevant citation for this product please let us know.

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Keywords: SKF 91488 dihydrochloride, supplier, Histamine, N-methyltransferase, inhibitors, transferases, Histaminergic-related, Compounds, Receptors, SKF91488, dihydrochloride, Other Transferase Inhibitors

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