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SKF 91488 dihydrochloride

Cat. No. 0512

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Chemical Name: 4-(N,N-Dimethylamino)butylisothiourea dihydrochloride

Biological Activity

Homolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.

Technical Data

M.Wt:

248.21

Formula:

C₇H₁₇N₃S.2HCl

Solubility:

Soluble to 75 mM in DMSO

Storage:

Store at RT

CAS No:

68643-23-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service

Safety Data Sheet: View Safety Data Sheet

References

Beaven and Shaff (1979) New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 28 183. PMID: 34400.

Beaven and Shaff (1979) Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 9 455. PMID: 161853.

Ohuri et al (1992) Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 261 1268. PMID: 1534842.

Aiello et al (1997) Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 355 354. PMID: 9089666.

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Histamine Receptors Histaminergic-Related Compounds

Other Transferases Transferases

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