SKF 91488 dihydrochloride
Cat. No. 0512
Chemical Name: 4-(N,N-Dimethylamino)butylisothiour
Biological ActivityHomolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Beaven and Shaff (1979) New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 28 183. PMID: 34400.
Beaven and Shaff (1979) Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 9 455. PMID: 161853.
Ohuri et al (1992) Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 261 1268. PMID: 1534842.
Aiello et al (1997) Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 355 354. PMID: 9089666.
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Keywords: SKF 91488 dihydrochloride, supplier, Histamine, N-methyltransferase, inhibitors, transferases, Histaminergic-related, Compounds, Receptors, SKF91488, dihydrochloride, Tocris Bioscience, Other Transferase Inhibitors