SKF 91488 dihydrochloride
Cat. No. 0512
Chemical Name: 4-(N,N-Dimethylamino)butylisothiour
Biological ActivityHomolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Beaven and Shaff (1979) New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 28 183. PMID: 34400.
Beaven and Shaff (1979) Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 9 455. PMID: 161853.
Ohuri et al (1992) Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 261 1268. PMID: 1534842.
Aiello et al (1997) Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 355 354. PMID: 9089666.
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Keywords: SKF 91488 dihydrochloride, supplier, Histamine, N-methyltransferase, inhibitors, transferases, Histaminergic-related, Compounds, Receptors, SKF91488, dihydrochloride
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