R&D Systems Inc. Tocris Bioscience Boston Biochem

Rolipram

Cat. No. 0905

Rolipram C16H21NO3 [61413-54-5]

Price and Availability

For Rolipram pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

Biological Activity

Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC50 = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes. Separate isomers (R)-(-)-Rolipram and (S)-(+)-Rolipram are available (Cat. Nos. 1349 and 1350 respectively).

Technical Data

M.Wt:
275.35
Formula:
C16H21NO3
Solubility:
Soluble to 75 mM in DMSO and to 75 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
61413-54-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

O'Donnell (1993) Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behaviour maintained by differential reinforcement of low response rate. J.Pharmacol.Exp.Ther. 264 1168. PMID: 8383740.

Kato et al (1995) Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil. Eur.J.Pharmacol. 272 107. PMID: 7713141.

Teixeira et al (1997) Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future? Trends Pharmacol.Sci. 18 164. PMID: 9184477.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Rolipram, supplier, PDE4, inhibitor, Phosphodiesterases

Quick Order

Find multiple products by catalog number

divider line

New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Poster

'New Therapies, Challenges, and Breakthroughs in Asthma' highlights key pathways and new therapies used to treat asthma, including those currently in clinical development.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

TC-E 5005

Potent and selective PDE10A inhibitor

Sign-up for new product e-alerts
divider line

Tocris Events

Physiology 2014

Physiology 2014

June 30 - July 2, 2014

London, UK

Booth Number: 39