Riluzole hydrochloride

Cat. No. 0768

Riluzole hydrochloride C8H5F3N2OS.HCl [850608-87-6]

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Chemical Name: 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride

Biological Activity

Novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes; neuroprotective.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in water with gentle warming
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Taylor and Meldrum (1995) Na+ channels as targets for neuroprotective drugs. TiPS 16 309. PMID: 7482996.

Umeniya and Berger (1995) Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. Br.J.Pharmacol. 116 3227. PMID: 8719800.

Song et al (1997) Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J.Pharmacol.Exp.Ther. 282 707. PMID: 9262334.

Fumagalli et al (2008) Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur.J.Pharmacol. 578 171. PMID: 18036519.

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Keywords: Riluzole hydrochloride, supplier, Glutamate, release, inhibitors, GABA, uptake, Na+, channel, blockers, glutamate, mGlur, Receptors, Metabotropic, Sodium, NaV, Channels, voltage-gated, voltage-dependent, iGlu, Ionotropic, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, neuroprotective, Tocris Bioscience, Miscellaneous Glutamate Inhibitors

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