R&D Systems Inc. Tocris Bioscience Boston Biochem

Remoxipride hydrochloride

Cat. No. 0916

Remoxipride hydrochloride C16H23BrN2O3.HCl [73220-03-8]

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Chemical Name: (S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylmethyl]2,6-dimethoxybenzamide hydrochloride

Biological Activity

Dopamine D2 receptor antagonist showing selectivity over D3 and D4 receptors (Ki values are ~ 300, ~ 1600, and ~ 2800 nM for D2, D3 and D4 receptors respectively). Exhibits antipsychotic activity in vivo with no extrapyramidal side effects. 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat.

Technical Data

M.Wt:
407.73
Formula:
C16H23BrN2O3.HCl
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
73220-03-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Sedvall (1990) Development of a new antipsychotic remoxipride. Acta Psychiatr.Scand.Suppl. 358 1. PMID: 1978466.

Mohell et al (1993) Binding characteristics of remoxipride and its metabolites to dopamine D2 and D3 receptors. Eur.J.Pharmacol. 238 121. PMID: 8405075.

Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264. PMID: 7940991.

Ahlenius et al (1997) In vivo effects of remoxipride and aromatic ring metabolites in the rat. J.Pharmacol.Exp.Ther. 283 1356. PMID: 9400011.

If you know of a relevant citation for this product please let us know.

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Keywords: Remoxipride hydrochloride, supplier, selective, D2-like, antagonists, dopamine, non-selective, receptor, antagonist, dopaminergic, d2

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