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PPADS tetrasodium salt

Cat. No. 0625

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Chemical Name: Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt

Biological Activity

A non-selective P2 purinergic antagonist. Blocks recombinant P2X₁, P2X₂, P2X₃, P2X₅ (IC₅₀ = 1 - 2.6 μM), native P2Y₂-like (IC₅₀ ~ 0.9 mM), and recombinant P2Y₄ (IC₅₀ ~ 15 mM) receptors. Delays onset of calcium responses to mild hypoosmotic stress in cortical slices. iso-PPADS (Cat. No. 0683) also available.

Technical Data

M.Wt:

599.3

Formula:

C₁₄H₁₀N₃Na₄O₁₂PS₂

Solubility:

Soluble to 100 mM in water

Storage:

Desiccate at -20°C

CAS No:

149017-66-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

2'5'-isomer Available

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Lambrecht et al (1992) PPADS, a novel functionally selective antagonist of P₂ purinoceptor-mediated responses. Eur.J.Pharmacol. 217 217. PMID: 1330591.

McLaren et al (1994) Investigation of the actions of PPADS, a novel P_2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens. Br.J.Pharmacol. 111 913. PMID: 8019769.

Ziganshin et al (1994) Selective antagonism by PPADS at P_2x-purinoceptors in rabbit isolated blood vessels. Br.J.Pharmacol. 111 923. PMID: 8019770.

Ralevic and Burnstock (1998) Receptors for purines and pyrimidines. Pharmacol.Rev. 50 413. PMID: 9755289.

Thrane et al (2011) Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc.Natl.Acad.Sci.U S A 108 846. PMID: 21187412.

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