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NF 449

Cat. No. 1391

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Chemical Name: 4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid, octasodium salt

Biological Activity

Potent purinergic receptor antagonist that displays high selectivity for P2X₁ (IC₅₀ values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X₁, rP2X₁₊₅, rP2X₂₊₃, rP2X₃, rP2X₂ and P2X₄ receptors respectively). Provides antithrombotic protection in vivo. Also acts as a G_sα-selective antagonist.

Technical Data

M.Wt:

1505.06

Formula:

C₄₁H₂₄N₆Na₈O₂₉S₈

Solubility:

Soluble to 50 mM in water with gentle warming

Storage:

Store at RT

CAS No:

389142-38-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Hohenegger et al (1998) G_sα-selective G protein antagonists. Proc.Natl.Acad.Sci.U.S.A. 95 346. PMID: 9419378.

Hechler et al (2005) Inhibition of platelet functions and thrombosis through selective or non-selective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4",4'"-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt]. J.Pharmacol.Exp.Ther. 314 232. PMID: 15792995.

Rettinger et al (2005) Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X₁ receptor antagonist. Neuropharmacology. 48 461. PMID: 15721178.

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9. PMID: 21164513.

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