R&D Systems Inc. Tocris Bioscience Boston Biochem

PD 123319 ditrifluoroacetate

Cat. No. 1361

PD 123319 ditrifluoroacetate C31H32N4O3.2CF3CO2H [130663-39-7]

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Chemical Name: 1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate

Biological Activity

Potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.

Technical Data

M.Wt:
736.67
Formula:
C31H32N4O3.2CF3CO2H
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
130663-39-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Blankley et al (1991) Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J.Med.Chem. 34 3248. PMID: 1956044.

Boulay et al (1992) Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol.Pharmacol. 41 809. PMID: 1569928.

Tamura et al (2000) Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats. J.Hypertens. 18 1239. PMID: 10994755.

If you know of a relevant citation for this product please let us know.

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Keywords: PD 123319 ditrifluoroacetate, supplier, Potent, selective, non-peptide, AT2, antagonists, Receptors, Angiotensin, PD123319, ditrifluoroacetate

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