PD 123319 ditrifluoroacetate
Cat. No. 1361
Chemical Name: 1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
Biological ActivityPotent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Blankley et al (1991) Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J.Med.Chem. 34 3248. PMID: 1956044.
Boulay et al (1992) Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol.Pharmacol. 41 809. PMID: 1569928.
Tamura et al (2000) Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats. J.Hypertens. 18 1239. PMID: 10994755.
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Keywords: PD 123319 ditrifluoroacetate, supplier, Potent, selective, non-peptide, AT2, antagonists, Receptors, Angiotensin, PD123319, ditrifluoroacetate
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