R&D Systems Inc. Tocris Bioscience Boston Biochem

PD 168077 maleate

Cat. No. 1065

PD 168077 maleate C20H22N4O.C4H4O4 [630117-19-0]

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Chemical Name: N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamide maleate

Biological Activity

A potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo.

Technical Data

M.Wt:
450.49
Formula:
C20H22N4O.C4H4O4
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
630117-19-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Glase et al (1997) Substituted [(4-phenylpiperazinyl)methyl]benzamides: selective dopamine D4 agonists. J.Med.Chem. 40 1771. PMID: 9191952.

Clifford and Waddington (2000) Topographically based search for an "Ethogram" among a series of novel D4 dopamine receptor agonists and antagonists. Neuropsychopharmacology 22 538. PMID: 10731629.

Gu et al (2006) Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol.Pharmacol. 69 813. PMID: 16365279.

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Keywords: PD 168077 maleate, supplier, High, affinity, selective, D4, agonists, Dopamine, Receptors, dopaminergic, PD168077, maleate

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