Phorbol 12-myristate 13-acetate

Cat. No. 1201

Phorbol 12-myristate 13-acetate C36H56O8 [16561-29-8]

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Alternative Name: PMA

Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a- (Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate

Biological Activity

Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a Ki value of 2.6 nM as measured by displacement of [3H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Desiccate at -20°C


Other Information

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Merck Index 12 7487.

Castagna et al (1982) Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J.Biol.Chem. 257 7847. PMID: 7085651.

Hockberger et al (1989) A diacylglycerol analogue reduces neuronal calcium currents independently of protein kinase C activation. Nature 338 340. PMID: 2922062.

Murphy et al (1999) Structural determinants of phorbol ester binding in synaptosomes: pharmacokinetics and pharmacodynamics. Eur.J.Pharmacol. 381 77. PMID: 10528137.

If you know of a relevant citation for this product please let us know.

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Keywords: Phorbol 12-myristate 13-acetate, supplier, Protein, kinases, C, activators, PKC, Phorbol12-myristate13-acetate

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