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SB 200646 hydrochloride

Cat. No. 1371

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Chemical Name: N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea

Biological Activity

5-HT_2C/2B receptor antagonist, selective over 5-HT_1A. Affinities are 7.4 (pA₂), 6.9 (pK_i) and 5.2 (pK_i) for 5-HT_2B, _2C and _2A respectively. Orally active in vivo.

Licensing Information

Sold under license

Technical Data

M.Wt:

302.76

Formula:

C₁₅H₁₄N₄O.HCl

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

143797-63-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Forbes et al (1993) N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT_1C receptor antagonist. J.Med.Chem. 36 1104. PMID: 8478907.

Kennett et al (1994) In vivo properties of SB 200646A, a 5-HT_2C/2B recepor antagonist. Br.J.Pharmacol. 111 797. PMID: 7912626.

Kennett et al (1995) Effect of SB 200646A, a 5-HT_2C/5-HT_2B receptor antagonist, in two conflict models of anxiety. Psychopharmacology (Berl.) 118 178. PMID: 7617805.

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