SB 200646 hydrochloride
Cat. No. 1371
Chemical Name: N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea
Biological Activity5-HT2C/2B receptor antagonist, selective over 5-HT1A. Affinities are 7.4 (pA2), 6.9 (pKi) and 5.2 (pKi) for 5-HT2B, 2C and 2A respectively. Orally active in vivo.
Licensing InformationSold under license
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Forbes et al (1993) N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist. J.Med.Chem. 36 1104. PMID: 8478907.
Kennett et al (1994) In vivo properties of SB 200646A, a 5-HT2C/2B recepor antagonist. Br.J.Pharmacol. 111 797. PMID: 7912626.
Kennett et al (1995) Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety. Psychopharmacology (Berl.) 118 178. PMID: 7617805.
If you know of a relevant citation for this product please let us know.
Keywords: SB 200646 hydrochloride, supplier, 5-HT2C/2B, antagonists, Serotonin, 5-HT2B, Receptors, SB200646, hydrochloride
Find multiple products by catalog number
New Products in this Area
Selective 5-HT2A antagonistQuetiapine hemifumarate
5-HT2/D2 antagonist; atypical antipsychoticS 32212 hydrochloride
5-HT2C inverse agonist; α2 antagonist
Meet your representative
October 15, 2013