Cat. No. 0680
Chemical Name: N-[2-(5-Methoxy-2-phenylindol-3-yl)
Biological ActivityHighly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC50 values for G protein activation in MT1 and MT2-transfected cells are 65 and 58 pM respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Spadoni et al (1993) 2-Substituted 5-methoxy-N-acetyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. J.Med.Chem. 36 4069. PMID: 8258829.
Nonno et al (1998) Pharmacological characterization of the human melatonin Mel1a receptor following stable transfection into NIH3T3 cells. Br.J.Pharmacol. 124 485. PMID: 9647472.
Nonno et al (1999) Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists. Br.J.Pharmacol. 127 1288. PMID: 10455277.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 2-Phenylmelatonin, supplier, Potent, melatonin, agonists, MT, Receptors, Melatonin Receptor Agonists
Find multiple products by catalog number
New Products in this Area
Potent and selective P2Y14 receptor agonistTreprostinil
Potent prostacyclin (PGI2) analogS 18886
Potent thromboxane A2 (TP) antagonistIHR 1
Potent Smo antagonistONO 8130
EP1 receptor antagonistTC-G 1008
Potent and selective GPR39 agonistRo 1138452 hydrochloride
Selective prostacyclin IP receptor antagonist
December 12 - 16, 2015
San Diego, CA