R&D Systems Inc. Tocris Bioscience Boston Biochem

2-Phenylmelatonin

Cat. No. 0680

2-Phenylmelatonin
 C19H20N2O2 [151889-03-1]

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Chemical Name: N-[2-(5-Methoxy-2-phenylindol-3-yl)ethyl]acetamide

Biological Activity

Highly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC50 values for G protein activation in MT1 and MT2-transfected cells are 65 and 58 pM respectively.

Technical Data

M.Wt:
308.38
Formula:
C19H20N2O2
Solubility:
Soluble to 100 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
151889-03-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Spadoni et al (1993) 2-Substituted 5-methoxy-N-acetyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. J.Med.Chem. 36 4069. PMID: 8258829.

Nonno et al (1998) Pharmacological characterization of the human melatonin Mel1a receptor following stable transfection into NIH3T3 cells. Br.J.Pharmacol. 124 485. PMID: 9647472.

Nonno et al (1999) Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists. Br.J.Pharmacol. 127 1288. PMID: 10455277.

If you know of a relevant citation for this product please let us know.

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Keywords: 2-Phenylmelatonin, supplier, Potent, melatonin, agonists, MT, Receptors

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