2-Phenylmelatonin

Cat. No. 0680

2-Phenylmelatonin C19H20N2O2 [151889-03-1]

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Chemical Name: N-[2-(5-Methoxy-2-phenylindol-3-yl)ethyl]acetamide

Biological Activity

Highly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC50 values for G protein activation in MT1 and MT2-transfected cells are 65 and 58 pM respectively.

Technical Data

M.Wt:
308.38
Formula:
C19H20N2O2
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
151889-03-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Spadoni et al (1993) 2-Substituted 5-methoxy-N-acetyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. J.Med.Chem. 36 4069. PMID: 8258829.

Nonno et al (1998) Pharmacological characterization of the human melatonin Mel1a receptor following stable transfection into NIH3T3 cells. Br.J.Pharmacol. 124 485. PMID: 9647472.

Nonno et al (1999) Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists. Br.J.Pharmacol. 127 1288. PMID: 10455277.

If you know of a relevant citation for this product please let us know.

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Keywords: 2-Phenylmelatonin, supplier, Potent, melatonin, agonists, MT, Receptors, Tocris Bioscience, Melatonin Receptor Agonists

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