R&D Systems Inc. Tocris Bioscience Boston Biochem

2-Phenylmelatonin

Cat. No. 0680

2-Phenylmelatonin
 C19H20N2O2 [151889-03-1]

Price and Availability

For 2-Phenylmelatonin pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[2-(5-Methoxy-2-phenylindol-3-yl)ethyl]acetamide

Biological Activity

Highly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC50 values for G protein activation in MT1 and MT2-transfected cells are 65 and 58 pM respectively.

Technical Data

M.Wt:
308.38
Formula:
C19H20N2O2
Solubility:
Soluble to 100 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
151889-03-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Spadoni et al (1993) 2-Substituted 5-methoxy-N-acetyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. J.Med.Chem. 36 4069. PMID: 8258829.

Nonno et al (1998) Pharmacological characterization of the human melatonin Mel1a receptor following stable transfection into NIH3T3 cells. Br.J.Pharmacol. 124 485. PMID: 9647472.

Nonno et al (1999) Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists. Br.J.Pharmacol. 127 1288. PMID: 10455277.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: 2-Phenylmelatonin, supplier, Potent, melatonin, agonists, MT, Receptors

Quick Order

Find multiple products by catalog number

divider line

7-TM Receptor Signaling

Written by T. Kenakin et al

7-TM Poster

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

New Products in this Area

ONO AE3 208

High affinity and selective EP4 antagonist

TCS 3035

GPR35 agonist

PF 5274857 hydrochloride

Potent and selective smoothened (Smo) receptor antagonist

GSK 137647

Potent and selective FFA4 (GPR120) agonist

AH 7614

Selective FFA4 (GPR120) antagonist

Prosaptide TX14(A)

Potent GPR37 and GPR37L1 agonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.