Cat. No. 1378
Alternative Name: BRL 38227
Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-d
Biological ActivityActive enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim (Cat. No. 1377). Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.
Licensing InformationSold under license
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Buckle et al (1991) Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 34 919. PMID: 2002472.
Noack et al (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945. PMID: 1467843.
Taylor et al (1992) The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 261 429. PMID: 1578358.
If you know of a relevant citation for this product please let us know.
Keywords: Levcromakalim, supplier, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, BRL38227
Find multiple products by catalog number
New Products in this Area
Potent and selective TASK-1 channel blockerHMR 1556
Potent and selective Iks channel blockerNS 19504
Activator of BKCa (KCa1.1) channelsTRAM 39
Potent KCa3.1 blocker
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.