Cat. No. 1378

Levcromakalim C16H18N2O3 [94535-50-9]

Price and Availability

For Levcromakalim pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: BRL 38227

Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

Biological Activity

Active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim (Cat. No. 1377). Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.

Licensing Information

Sold under license

Technical Data

Soluble to 10 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Buckle et al (1991) Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 34 919. PMID: 2002472.

Noack et al (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945. PMID: 1467843.

Taylor et al (1992) The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 261 429. PMID: 1578358.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: Levcromakalim, supplier, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, BRL38227, Inward Rectifier Potassium (Kir) Channel Activators

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Pain Research Product Guide

Pain Research Product Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

New Products in this Area

Guangxitoxin 1E

Potent Kv2.1 and Kv2.2 channel blocker


KV4 channel blocker


Potent TREK-1 channel blocker

Lei-Dab 7

High affinity, selective KCa2.2 blocker

NS 8593 hydrochloride

Selective KCa2 (SK) channel negative modulator; inhibits SK currents

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ASCB 2015

ASCB 2015

December 12 - 16, 2015

San Diego, CA