R&D Systems Inc. Tocris Bioscience Boston Biochem

Levcromakalim

Cat. No. 1378

Levcromakalim C16H18N2O3 [94535-50-9]

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Alternative Name: BRL 38227

Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

Biological Activity

Active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim (Cat. No. 1377). Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.

Licensing Information

Sold under license

Technical Data

M.Wt:
286.33
Formula:
C16H18N2O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
94535-50-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Buckle et al (1991) Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 34 919. PMID: 2002472.

Noack et al (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945. PMID: 1467843.

Taylor et al (1992) The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 261 429. PMID: 1578358.

If you know of a relevant citation for this product please let us know.

Keywords: Levcromakalim, supplier, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, BRL38227

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