Cat. No. 1378
Alternative Name: BRL 38227
Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-d
Biological ActivityActive enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim (Cat. No. 1377). Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.
Licensing InformationSold under license
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Buckle et al (1991) Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 34 919. PMID: 2002472.
Noack et al (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945. PMID: 1467843.
Taylor et al (1992) The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 261 429. PMID: 1578358.
If you know of a relevant citation for this product please let us know.
View Related Products by Product Action
Keywords: Levcromakalim, supplier, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, BRL38227, Inward Rectifier Potassium (Kir) Channel Activators
Find multiple products by catalog number
New Products in this Area
Potent Kv2.1 and Kv2.2 channel blockerAmmTX3
KV4 channel blockerSpadin
Potent TREK-1 channel blockerLei-Dab 7
High affinity, selective KCa2.2 blockerNS 8593 hydrochloride
Selective KCa2 (SK) channel negative modulator; inhibits SK currents
December 12 - 16, 2015
San Diego, CA