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BYK 191023 dihydrochlorideCat. No. 2866 |
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Chemical Name: 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride |
Biological Activity
Potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 values are 86, 17000, 162000 nM for iNOS, nNOS and eNOS respectively). Acts in an NADPH- and time-dependent manner. Active in vivo, reverses pathological hypotension in the rodent endotoxin model.Licensing Information
Sold with the permission of NycomedCertificate of Analysis / Safety Data Sheet
References
Lehner et al (2006) In vivo characterisation of the novel imidazopyridine BYK191023 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine, a potent and highly selective inhibitor of inducible nitric-oxide synthase. J.Pharmacol.Exp.Ther. 317 181. PMID: 16368897.
Strub et al (2006) The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase. Mol.Pharmacol. 68 328.
Tiso et al (2008) BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. Mol.Pharmacol. 72 1244.
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Keywords: BYK 191023 dihydrochloride, supplier, Potent, selective, inhibitors, iNOS, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, BYK191023, dihydrochloride
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