BYK 191023 dihydrochloride
Cat. No. 2866
Chemical Name: 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride
Biological ActivityPotent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 values are 86, 17000, 162000 nM for iNOS, nNOS and eNOS respectively). Acts in an NADPH- and time-dependent manner. Active in vivo, reverses pathological hypotension in the rodent endotoxin model.
Licensing InformationSold with the permission of Nycomed
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Lehner et al (2006) In vivo characterisation of the novel imidazopyridine BYK191023 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine, a potent and highly selective inhibitor of inducible nitric-oxide synthase. J.Pharmacol.Exp.Ther. 317 181. PMID: 16368897.
Strub et al (2006) The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase. Mol.Pharmacol. 68 328.
Tiso et al (2008) BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. Mol.Pharmacol. 72 1244.
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Keywords: BYK 191023 dihydrochloride, supplier, Potent, selective, inhibitors, iNOS, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, BYK191023, dihydrochloride
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