Cat. No. 0942
Chemical Name: N-[2-Cyclohexyloxy-4-nitrophenyl]me
Biological ActivitySelective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro. Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Futaki et al (1993) NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen.Pharmacol. 24 105. PMID: 8482483.
Futaki et al (1994) NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47 55. PMID: 8140262.
Elder et al (2002) The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. Int.J.Cancer 99 323. PMID: 11992399.
If you know of a relevant citation for this product please let us know.
Keywords: NS 398, supplier, Cyclooxygenase, COX-2, inhibitor, COX, Oxygenases, Oxidases, NS398
Find multiple products by catalog number
New Products in this Area
Aldehyde oxidase substrate; PDE inhibitor
Win a Kindle
March 18 - 21, 2014
University of Regensburg, Germany
Booth Number: 44