Cat. No. 2643
Alternative Name: (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride
Chemical Name: 4-Iodo-2,5-dimethoxy-α-methylbenzene
Biological ActivityBrain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)-α.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Nelson et al (1999) Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn-Schmied.Arch.Pharmacol. 359 1.
Monti and Jantos (2006) Effects of serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213 respectively, on sleep and waking in the rat. Eur.J.Pharmacol. 553 163. PMID: 17059817.
Yu et al (2008) Serotonin 5-hydroxytryptamine2A receptor activation suppresses tumor necrosis factor-α-induced inflammation with extraordinary potency. J.Pharmacol.Exp.Ther. 327 316. PMID: 18708586.
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Keywords: DOI hydrochloride, supplier, Mixed, 5-H2A, 5-HT2C, agonists, serotonin, receptors, 5-hydroxytryptamine