R&D Systems Inc. Tocris Bioscience Boston Biochem

α-helical CRF 9-41

Cat. No. 1184

a-helical CRF 9-41 Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2

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Alternative Name: α-helical-Corticotropin-Releasing Factor 9-41

Biological Activity

Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).

Licensing Information

Sold with the permission of the SALK Institute

Technical Data

M.Wt:
3827
Formula:
C166H274N46O53S2
Sequence:
DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA

(Modifications: Ala-33 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 0.1% TFA
Storage:
Desiccate at -20°C
CAS No:
90880-23-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Swerdlow et al (1989) Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by α-helical CRF (9-41). Neuropsychopharmacology 2 285. PMID: 2610824.

Kask et al (1997) Alpha-helical(9-41) revents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226. NeuroReport 8 3645. PMID: 9427342.

Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312. PMID: 10816663.

If you know of a relevant citation for this product please let us know.

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