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Naltrindole hydrochlorideCat. No. 0740 |
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Chemical Name: 17-(Cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride |
Biological Activity
Highly selective non-peptide δ opioid antagonist, showing 223- and 346-fold greater activity at δ than at μ and κ opioid receptors.Licensing Information
Sold with the permission of the University of Minnesota.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
References
Portoghese et al (1990) Design of peptidomimetic δ opioid receptor antagonists using the message-address concept. J.Med.Chem. 33 1714. PMID: 2160538.
Ossipov et al (1994) Naltrindole, an opioid δ antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat. Neurosci. Lett. 181 9. PMID: 7898778.
Shippenberg and Heidbreder (1995) The δ-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine. Eur.J.Pharmacol. 280 55. PMID: 7498254.
If you know of a relevant citation for this product please let us know.
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Keywords: Naltrindole hydrochloride, supplier, δ-opioid, delta-opioid, selective, non-peptide, antagonists, DOP, Receptors, OP1
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