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Cyprodime hydrochloride

Cat. No. 2601

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Chemical Name: 17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one hydrochloride

Biological Activity

Selective μ-opioid receptor antagonist (K_i values are 5.4, 244.6 and 2187 nM for μ-, δ- and κ-opioid receptors respectively). Reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

Technical Data

M.Wt:

391.93

Formula:

C₂₂H₂₉NO₃.HCl

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

118111-54-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Schmidhammer et al (1995) Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime. J.Med.Chem. 38 3071. PMID: 7636870.

Marki et al (1999) μ-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [³⁵S]GTPγs binding assays. Eur.J.Pharmacol. 383 209. PMID: 10585536.

Henry et al (2001) μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Exp.Neurol. 171 139. PMID: 11520128.

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