Cat. No. 2600
Chemical Name: 2-Chloro-9-(2-deoxy-2-fluoro-β-D-ara
Biological ActivityDeoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Parker et al (1991) Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res. 51 2386. PMID: 1707752.
Carson et al (1992) Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. Proc.Natl.Acad.Sci.USA 89 2970.
Bonate et al (2006) Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nat.Rev.Drug Discov. 5 855. PMID: 17016426.
If you know of a relevant citation for this product please let us know.
View Related Products by Product Action
Keywords: Clofarabine, supplier, Deoxycytidine, kinases, dCK, Enzyme, Substrates, activators, antimetabolites, Tocris Bioscience, Other Kinase Substrates
Find multiple products by catalog number
New Products in this Area
PKC activator; also NF-κB activatorTBCA
Selective CK2 inhibitorMSC 2032964A
Potent and selective ASK1 inhibitor; orally bioavailableCW 008
PKA signaling activator; promotes osteogenesis from hMSCsPF 06447475
Potent LRRK2 inhibitor; neuroprotectiveAMG PERK 44
Potent and selective PERK inhibitor; orally bioavailableCGP 60474
Potent dual cdk1/cdk2 inhibitorCGP 74514 dihydrochloride
Potent cdk1 inhibitorKG 5
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitorNilvadipine
Syk kinase inhibitor; inhibits Aβ productionCentrinone B
High affinity and selective PLK4 inhibitorHTH 01-015
Potent and selective NUAK1 inhibitorKobe 0065
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signalingOSU 03012
PDK1 inhibitor; inhibits Akt signalingSR 7826
Potent and selective LIMK inhibitor; antitumorMps BAY 2a
Potent and selective Mps1 kinase inhibitorNG 25
TGF-β-activated kinase (TAK1) inhibitorMI 14
Potent and selective PI 4-kinase IIIβ inhibitorCTA 056
ITK inhibitorAZD 1480
Potent and selective JAK2 inhibitor; antiangiogenicTC-S 7001
Potent and highly selective ROCK inhibitor; orally activeAS 2444697
Potent and selective IRAK4 inhibitor
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for AACR 2016.