Pepstatin A

Cat. No. 1190

Pepstatin A H-iso-Valeryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic-acid

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Biological Activity

Irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).

Technical Data

M.Wt:
685.89
Formula:
C34H63N5O9
Sequence:
VVA

(Modifications: Val-1 = N-terminal H-iso-Valeryl, Val-2 = Val-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-4-amino-3-hydroxy-6-methylheptanoic-acid)

Solubility:
Soluble to 1 mg/ml in ethanol with gentle warming
Storage:
Desiccate at -20°C
CAS No:
26305-03-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 7290.

Marciniszyn et al (1976) Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 251 7088. PMID: 993206.

Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677. PMID: 17942897.

If you know of a relevant citation for this product please let us know.

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Keywords: Pepstatin A, supplier, Aspartic, protease, inhibitors, Proteases, Proteinases, PepstatinA, Tocris Bioscience, Other Protease Inhibitors

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