R&D Systems Inc. Tocris Bioscience Boston Biochem

Pepstatin A

Cat. No. 1190

Pepstatin A H-iso-Valeryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic-acid

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Biological Activity

Irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).

Technical Data

M.Wt:
685.89
Formula:
C34H63N5O9
Sequence:
VVA

(Modifications: Val-1 = N-terminal H-iso-Valeryl, Val-2 = Val-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-4-amino-3-hydroxy-6-methylheptanoic-acid)

Solubility:
Soluble to 1 mg/ml in ethanol with gentle warming
Storage:
Desiccate at -20°C
CAS No:
26305-03-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 7290.

Marciniszyn et al (1976) Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 251 7088. PMID: 993206.

Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677. PMID: 17942897.

If you know of a relevant citation for this product please let us know.

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Keywords: Pepstatin A, supplier, Aspartic, protease, inhibitors, Proteases, Proteinases, PepstatinA

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