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Muscimol

Cat. No. 0289

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Chemical Name: 5-Aminomethyl-3-hydroxyisoxazole

Biological Activity

Potent GABA_A receptor agonist and partial GABA_C receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo.

Technical Data

M.Wt:

114.1

Formula:

C₄H₆N₂O₂

Solubility:

Soluble to 100 mM in water

Purity:

>98 %

Storage:

Store at RT

CAS No:

2763-96-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Johnston et al (1968) Central actions of ibotenic acid and muscimol. Biochem.Pharmacol. 17 2488. PMID: 5752907.

Akhondzadeh and Stone (1995) Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABA_A but not glutamate receptors. Br.J.Pharmacol. 115 527. PMID: 7582468.

Johnstone (1996) GABA_C receptors: relatively simple transmitter-gated ion channels? TiPS 17 319. PMID: 8885697.

Gleason et al (2009) The GABA_A agonist muscimol attenuates induced airway constriction in guinea pigs in vivo. J.Appl.Physiol. 106 1257. PMID: 19213928.

Jafari-Sabet and Jannat-Dastjerdi (2009) Muscimol state-dependent memory: involvement of dorsal hippocampal μ-opioid receptors. Behav.Brain Res. 202 5. PMID: 19447274.

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