Muscimol

Cat. No. 0289

Muscimol C4H6N2O2 [2763-96-4]

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Chemical Name: 5-Aminomethyl-3-hydroxyisoxazole

Biological Activity

Potent GABAA receptor agonist and partial GABAA-ρ receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo.

Technical Data

M.Wt:
114.1
Formula:
C4H6N2O2
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
2763-96-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Johnston et al (1968) Central actions of ibotenic acid and muscimol. Biochem.Pharmacol. 17 2488. PMID: 5752907.

Akhondzadeh and Stone (1995) Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors. Br.J.Pharmacol. 115 527. PMID: 7582468.

Johnstone (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319. PMID: 8885697.

Gleason et al (2009) The GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo. J.Appl.Physiol. 106 1257. PMID: 19213928.

Jafari-Sabet and Jannat-Dastjerdi (2009) Muscimol state-dependent memory: involvement of dorsal hippocampal μ-opioid receptors. Behav.Brain Res. 202 5. PMID: 19447274.

If you know of a relevant citation for this product please let us know.

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Keywords: Muscimol, supplier, Potent, GABAA, agonists, Partial, GABAC, Receptors, Tocris Bioscience, GABAA Receptor Agonists

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