TCS 359

Cat. No. 2591

TCS 359 C18H20N2O4S [301305-73-7]

Price and Availability

For TCS 359 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide

Biological Activity

Potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).

Technical Data

M.Wt:
360.43
Formula:
C18H20N2O4S
Solubility:
Soluble to 30 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
301305-73-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Patch et al (2006) Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 16 3282. PMID: 16580199.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: TCS 359, supplier, Potent, FLT3, inhibitors, RTKs, Receptor, Tyrosine, Kinases, TCS359

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

New Product Guide

NPG

Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

Crizotinib

Potent c-MET/ALK inhibitor

AC 710

Potent and selective PDGFR family inhibitor

SPP 86

Potent RET inhibitor

SGX 523

Selective and potent c-MET kinase inhibitor

NBI 31772

High affinity insulin-like growth factor-I binding protein IGFBP inhibitor

APcK 110

KIT inhibitor

Norleual

Highly potent HGF/c-MET inhibitor; also AT4 antagonist

AEE 788

Potent EGFR and VEGFR inhibitor

XL 184

Potent VEGFR inhibitor; also inhibits other RTKs

Sign-up for new product e-alerts
divider line

Bio-Techne Events

EMBO 2015

The 6th EMBO Meeting 2015

September 5 - 8, 2015

Birmingham, UK