R&D Systems Inc. Tocris Bioscience Boston Biochem

TCS 359

Cat. No. 2591

TCS 359 C18H20N2O4S [301305-73-7]

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Chemical Name: 2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide

Biological Activity

Potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).

Technical Data

M.Wt:
360.43
Formula:
C18H20N2O4S
Solubility:
Soluble to 30 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
301305-73-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Patch et al (2006) Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 16 3282. PMID: 16580199.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: TCS 359, supplier, Potent, FLT3, inhibitors, RTKs, Receptor, Tyrosine, Kinases, TCS359

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