Cat. No. 2591
Chemical Name: 2-[(3,4-Dimethoxybenzoyl)amino]-4,5
Biological ActivityPotent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Patch et al (2006) Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 16 3282. PMID: 16580199.
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Keywords: TCS 359, supplier, Potent, FLT3, inhibitors, RTKs, Receptor, Tyrosine, Kinases, TCS359
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