Cat. No. 0854
Chemical Name: (RS)-α-Methyl-4-sulfonophenylglycine
Biological ActivityRelatively non-selective antagonist of presynaptic mGlu receptors in neonatal rat spinal cord and adult rat cerebrocortical mGlu receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jane et al (1995) New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology 34 851. PMID: 8532166.
Thomas et al (1995) Antagonism of L-AP4- and (1S,3S)-ACPD-induced depression of dorsal root-evoked monosynaptic excitation of neonatal rat motoneurones by the novel antagonists MSPG and MPPG. Br.J.Pharmacol. 114 9P.
Bedingfield et al (1996) Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. Eur.J.Pharmacol. 309 71. PMID: 8864696.
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Keywords: MSPG, supplier, Group, III, group, II, mGlur, antagonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, mGlu2, mGlu3, mGluR2, mGluR3
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Potent and selective negative allosteric modulator at mGlu1; also mGlu1 inverse agonist
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