R&D Systems Inc. Tocris Bioscience Boston Biochem

MAFP

Cat. No. 1421

MAFP C21H36FO2P [188404-10-6]

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Chemical Name: (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyl-methyl ester phosphonofluoridic acid

Biological Activity

Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC50 = 2.5 nM). Also binds irreversibly to CB1 receptors (IC50 = 20 nM).

Technical Data

M.Wt:
370.49
Formula:
C21H36FO2P
Solubility:
Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
Storage:
Desiccate at -80°C
CAS No:
188404-10-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

De Petrocellis et al (1997) Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase. Biochem.Biophys.Res.Commun. 231 82. PMID: 9070224.

Deutsch et al (1997) Methyl arachidonyl fluorophosphate: a potent irreversible inhibitor of anandamide amidase. Biochem.Pharmacol. 53 255. PMID: 9065728.

Martin et al (2000) Cannabinoid properties of methylfluorophosphonate analogs. J.Pharmacol.Exp.Ther. 294 1209. PMID: 10945879.

If you know of a relevant citation for this product please let us know.

Keywords: MAFP, supplier, Potent, irreversible, FAAH, inhibitors, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, Cannabinoids, Receptors

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