Cat. No. 1421
Chemical Name: (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatet
Biological ActivityPotent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC50 = 2.5 nM). Also binds irreversibly to CB1 receptors (IC50 = 20 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
De Petrocellis et al (1997) Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase. Biochem.Biophys.Res.Commun. 231 82. PMID: 9070224.
Deutsch et al (1997) Methyl arachidonyl fluorophosphate: a potent irreversible inhibitor of anandamide amidase. Biochem.Pharmacol. 53 255. PMID: 9065728.
Martin et al (2000) Cannabinoid properties of methylfluorophosphonate analogs. J.Pharmacol.Exp.Ther. 294 1209. PMID: 10945879.
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Keywords: MAFP, supplier, Potent, irreversible, FAAH, inhibitors, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, Cannabinoids, Receptors
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