R&D Systems Inc. Tocris Bioscience Boston Biochem


Cat. No. 1421

MAFP C21H36FO2P [188404-10-6]

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Chemical Name: (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyl-methyl ester phosphonofluoridic acid

Biological Activity

Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC50 = 2.5 nM). Also binds irreversibly to CB1 receptors (IC50 = 20 nM).

Technical Data

Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
Desiccate at -80°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet


De Petrocellis et al (1997) Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase. Biochem.Biophys.Res.Commun. 231 82. PMID: 9070224.

Deutsch et al (1997) Methyl arachidonyl fluorophosphate: a potent irreversible inhibitor of anandamide amidase. Biochem.Pharmacol. 53 255. PMID: 9065728.

Martin et al (2000) Cannabinoid properties of methylfluorophosphonate analogs. J.Pharmacol.Exp.Ther. 294 1209. PMID: 10945879.

If you know of a relevant citation for this product please let us know.

Keywords: MAFP, supplier, Potent, irreversible, FAAH, inhibitors, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, Cannabinoids, Receptors

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