R&D Systems Inc. Tocris Bioscience Boston Biochem

Compstatin

Cat. No. 2585

Compstatin Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: 2 -12)

Price and Availability

For Compstatin pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in baboons.

Technical Data

M.Wt:
1550.77
Formula:
C66H99N23O17S2
Sequence:
ICVVQDWGHHRCT

(Modifications: Thr-13 = C-terminal amide, Disulfide bridge between 2 - 12)

Solubility:
Soluble to 2 mg/ml in 30% acetonitrile / water
Storage:
Store at -20°C
CAS No:
206645-99-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Sahu et al (1996) Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J.Immunol. 157 884. PMID: 8752942.

Fiane et al (1999) Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 6 52. PMID: 10355733.

Soulika et al (2000) Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons. Clin.Immunol. 96 212. PMID: 10964539.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Compstatin, supplier, C3-binding, protein, inhibits, inhibitors, complement, activation, Convertase

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Immunology Guide

Immunology Research Guide

Highlights over 150 products for immunology research. Request a copy or view PDF today.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

AZ 12080282 dihydrochloride

Inhibitor of Hedgehog (Hh) signaling

Sign-up for new product e-alerts
divider line

Tocris Events

Immunology 2014

Immunology 2014

May 2-6, 2014

Pittsburgh, Pennsylvania

Booth Number: 523