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α-MSH

Cat. No. 2584

a-MSH Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

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Alternative Names: α-Melanotropin, α-Melanocyte-stimulating hormone

Biological Activity

Endogenous melanocortin receptor agonist (K_i values are 0.12, 31, 660 and 5700 nM for MC₁, MC₃, MC₄ and MC₅ receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

Technical Data

M.Wt:

1664.9

Formula:

C₇₇H₁₀₉N₂₁O₁₉S

Sequence:

SYSMEHFRWGKPV

(Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide)

Solubility:

Soluble to 0.60 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

581-05-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295. PMID: 10443584.

Mizusawa et al (2002) Alpha-melanocyte stimulating hormone and oxytocin induced penile erections, and intracavernous pressure increases in the rat. J.Urol. 167 757. PMID: 11792967.

Yamaoka-Tojo et al (2006) Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med. 45 429. PMID: 16679696.

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Keywords: a-MSH, supplier, Endogenous, melanocortin, receptor, agonists, MC, Receptors, Melanocortin, α-MSH, alpha-MSH, α-Melanocyte-stimulating, alpha-Melanocyte-stimulating, hormone, α-Melanotropin, alpha-Melanotropin, a-MSH

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