Cat. No. 2579
Alternative Name: UK 76654
Chemical Name: (3R)-1-[2-(1-,3-Benzodioxol-5-yl)et
Biological ActivitySelective M3 muscarinic receptor antagonist (pKi values are 8.52, 7.93, 7.90 and 7.78 for M3, M2, M1 and M4 receptors respectively). Displays higher affinity at ileal M3 receptors (pKi = 9.3) compared to oesophageal and tracheal M3 receptors (pKi values are 8.8 and 8.2 respectively). Inhibits gastrointestinal motility in vivo in the absence of cardiovascular effects.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Wallis (1995) Pre-clinical and clinical pharmacology of selective muscarinic M3 receptor antagonists. Life Sci. 56 861. PMID: 10188786.
Watson et al (1995) Characterization of the interaction of zamifenacin at muscarinic receptors in vitro. Eur.J.Pharmacol. 285 135. PMID: 8566131.
Choppin (2002) Muscarinic receptors in isolated urinary bladder smooth muscle from different mouse strains. Br.J.Pharmacol. 137 522. PMID: 12359634.
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Keywords: Zamifenacin fumarate, supplier, Selective, M3, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, UK76654
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July 15, 2014