Cat. No. 2575
Chemical Name: N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-isoleucyl-L-leucine
Biological ActivityInhibitor of the major neurotensin and neuromedin N degrading enzymes (IC50 values are 31, 40, 52 and 58 for endopeptidase 24.15, endopeptidase 24.11, leucine aminopeptidase and endopeptidase 24.16 respectively). Exhibits analgesic effects in various nociception assays.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Kitabgi et al (1992) Effects of thiorphan, bestatin and a novel metallopeptidase inhibitor JMV 390-1 on the recovery of neurotensin and neuromedin N released from mouse hypothalamus. Neurosci.Lett. 142 200. PMID: 1454216.
Doulut et al (1993) Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes. J.Med.Chem. 36 1369. PMID: 8496905.
Menard et al (1996) The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors. Biochem.J. 320 687. PMID: 8973585.
If you know of a relevant citation for this product please let us know.
Keywords: JMV 390-1, supplier, JMV390-1, endopeptidases, 24.15, 24.11, 24.16, inhibitors, neurotensin, neuromedin, n, analgesics
Find multiple products by catalog number
New Products in this Area
γ-secretease inhibitor; inhibits Notch pathwayCA 074
Selective cathepsin B inhibitorP005091
Win a Kindle
June 12 - 15, 2013
Booth Number: 213