Home » Pharmacology » Enzymes » Proteases » Other Proteases » JMV 390-1

JMV 390-1

Cat. No. 2575

Price and Availability

For JMV 390-1 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-isoleucyl-L-leucine

Biological Activity

Inhibitor of the major neurotensin and neuromedin N degrading enzymes (IC₅₀ values are 31, 40, 52 and 58 for endopeptidase 24.15, endopeptidase 24.11, leucine aminopeptidase and endopeptidase 24.16 respectively). Exhibits analgesic effects in various nociception assays.

Technical Data

M.Wt:

449.54

Formula:

C₂₃H₃₅N₃O₆

Sequence:

XIL (Modifications: X-1 = N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl])

Solubility:

Soluble to 0.80 mg/ml in sodium bicarbonate (0.01M)

Storage:

Store at -20°C

CAS No:

148473-36-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Kitabgi et al (1992) Effects of thiorphan, bestatin and a novel metallopeptidase inhibitor JMV 390-1 on the recovery of neurotensin and neuromedin N released from mouse hypothalamus. Neurosci.Lett. 142 200. PMID: 1454216.

Doulut et al (1993) Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes. J.Med.Chem. 36 1369. PMID: 8496905.

Menard et al (1996) The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A₄ hydrolase and metallopeptidase inhibitors. Biochem.J. 320 687. PMID: 8973585.

If you know of a relevant citation for this product please let us know.