Home » Research Area » » Ion Channels » Calcium Channels » Voltage-gated Calcium Channels (Ca_V) » Amlodipine besylate

Amlodipine besylate

Cat. No. 2571

Price and Availability

For Amlodipine besylate pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Norvasc

Chemical Name: 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate

Biological Activity

L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca²⁺-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC₅₀ = 25 μM).

Technical Data

M.Wt:

567.05

Formula:

C₂₀H₂₅ClN₂O₅.C₆H₆O₃S

Solubility:

Soluble to 10 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

111470-99-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Burges et al (1987) Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J.Cardiovasc.Pharmacol. 9 110. PMID: 2434785.

Yoshida et al (2003) Antiproliferative effect of Ca²⁺ channel blockers on human epidermoid carcinoma A431 cells. Eur.J.Pharmacol. 472 23. PMID: 12860469.

Toba et al (2005) Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N^G-nitro-L-arginine methyl ester-induced hypertensive rat aorta: vasoprotective effects beyond the blood pressure-lowering effects of amlodipine and manidipine. Hypertens.Res. 28 689. PMID: 16392774.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Calcium Channels

Voltage-gated Calcium Channels (Ca_V)

Keywords: Amlodipine besylate, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent

Quick Order

Find multiple products by catalog number

Pain Research Guide

Reserve your free copy

Highlights over 280 products for Pain research. Reserve copy

Calcium Imbalance and Neuroprotective Targets

Written by E. Besancon et al

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.