PLP (139-151)

Cat. No. 2567

PLP (139-151) His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe

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Alternative Name: Proteolipid protein (139-151)

Biological Activity

Synthetic myelin proteolipid protein (PLP) fragment. Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis.

Technical Data

M.Wt:
1521.74
Formula:
C72H104N20O17
Sequence:
HSLGKWLGHPDKF
Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
122018-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Tuohy et al (1989) Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J.Immunol. 142 1523. PMID: 2465343.

Sobel et al (1990) Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein. J.Neuropathol.Exp.Neurol. 49 468. PMID: 2273404.

Kuchroo et al (1991) Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 59 305. PMID: 1716908.

If you know of a relevant citation for this product please let us know.

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Keywords: PLP (139-151), supplier, Encephalitogenic, myelin, proteolipid, fragment, Neuronal, Metabolism, Tocris Bioscience, Neuronal Metabolism

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