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2-Methyl-5-hydroxytryptamine hydrochloride

Cat. No. 0558

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Biological Activity

5-HT₃ agonist (K_i = 1200 nM) and potent 5-HT₆ ligand (K_i = 46 nM).

Technical Data

M.Wt:

226.71

Formula:

C₁₁H₁₄N₂O.HCl

Solubility:

Soluble to 100 mM in water

Purity:

>98 %

Storage:

Store at RT

CAS No:

78263-90-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Craig et al (1990) 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT₃ and putative 5-HT₄ receptors in guinea pig ileum. Naunyn Schmiedebergs Arch.Pharmacol. 342 9. PMID: 2402303.

Ismaiel et al (1990) 5-HT₁ and 5-HT₂ binding profiles of the serotonergic agents α-methyl serotonin and 2-methylserotonin. J.Med.Chem. 33 755. PMID: 2299641.

Wilson et al (1990) 5-Hydroxytryptamine₃ receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 252 683. PMID: 1968974.

Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT₆ serotonin receptors. J.Med.Chem. 43 1011. PMID: 10715164.

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