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10-DEBC hydrochloride

Cat. No. 2558

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Chemical Name: 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride

Biological Activity

Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC₅₀ ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.

Technical Data

M.Wt:

381.34

Formula:

C₂₀H₂₅N₂OCl.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

201788-90-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Thimmaiah et al (1992) Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells. J.Med.Chem. 35 3358. PMID: 1527786.

Thimmaiah et al (2005) Identification of N¹⁰-substituted phenoxazines as potent and specific inhibitors of Akt signaling. J.Biol.Chem. 36 31924.

If you know of a relevant citation for this product please let us know.

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Keywords: 10-DEBC hydrochloride, supplier, Selective, Akt, PKB, inhibitors, Protein, Kinase, B, Kinases

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