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SYM 2081

Cat. No. 0903

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Chemical Name: (2S,4R)-4-Methylglutamic acid

Biological Activity

Potent and highly selective kainate receptor agonist, with an IC₅₀ for inhibition of [³H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ and Kainate Receptor Tocriset™.

Licensing Information

Sold with the permission of Annovis Inc.

Technical Data

M.Wt:

161.16

Formula:

C₆H₁₁NO₄

Solubility:

Soluble to 50 mM in water

Purity:

>97 %

Storage:

Store at RT

CAS No:

31137-74-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Jones et al (1997) Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate. Neuropharmacology 36 853. PMID: 9225313.

Zhou et al (1997) (2S,4R)-4-Methylglutamic acid (SYM 2081): a selective, high affinity ligand for kainate receptors. J.Pharmacol.Exp.Ther. 280 422. PMID: 8996224.

Donevan et al (1998) The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors. J.Pharmacol.Exp.Ther. 285 539. PMID: 9580595.

Savidge et al (1999) Characterisation of kainate receptor mediated whole-cell currents in rat cultured cerebellar granule cells. Neuropharmacology 38 375. PMID: 10219975.

If you know of a relevant citation for this product please let us know.

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Keywords: SYM 2081, supplier, Inhibitor, EAAT2, kainate, receptors, agonist, selective, EAAT, Excitatory, Amino, Acid, Transporters, GLT-1, Glutamate, Monoamine, Neurotransmitter, iGluR, Ionotropic, SYM2081

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