ZIP

Cat. No. 2549

ZIP Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu

Price and Availability

For ZIP pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: z-Pseudosubstrate inhibitory peptide

Biological Activity

Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Control and biotinylated peptides (Cat. Nos. 3215 and 3290) also available.

Technical Data

M.Wt:
1928.4
Formula:
C90H154N30O17
Sequence:
SIYRRGARRWRKL

(Modifications: Ser-1 = Myr-Ser)

Solubility:
Soluble to 1 mg/ml in 20% ethanol / water
Storage:
Desiccate at -20°C
CAS No:
863987-12-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295.

Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979. PMID: 15728837.

Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141. PMID: 16931766.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: ZIP, supplier, Cell-permeable, inhibitors, atypical, PKC, isozyme, PKMzeta, Protein, Kinases, C, Tocris Bioscience, Protein Kinase C Inhibitors

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Pain Research Product Guide

Pain Research Product Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

New Products in this Area

Prostratin

PKC activator; also NF-κB activator

TBCA

Selective CK2 inhibitor

MSC 2032964A

Potent and selective ASK1 inhibitor; orally bioavailable

CW 008

PKA signaling activator; promotes osteogenesis from hMSCs

PF 06447475

Potent LRRK2 inhibitor; neuroprotective

AMG PERK 44

Potent and selective PERK inhibitor; orally bioavailable

CGP 60474

Potent dual cdk1/cdk2 inhibitor

CGP 74514 dihydrochloride

Potent cdk1 inhibitor

KG 5

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Nilvadipine

Syk kinase inhibitor; inhibits Aβ production

Centrinone B

High affinity and selective PLK4 inhibitor

HTH 01-015

Potent and selective NUAK1 inhibitor

Kobe 0065

H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling

OSU 03012

PDK1 inhibitor; inhibits Akt signaling

SR 7826

Potent and selective LIMK inhibitor; antitumor

Mps BAY 2a

Potent and selective Mps1 kinase inhibitor

NG 25

TGF-β-activated kinase (TAK1) inhibitor

MI 14

Potent and selective PI 4-kinase IIIβ inhibitor

CTA 056

ITK inhibitor

AZD 1480

Potent and selective JAK2 inhibitor; antiangiogenic

TC-S 7001

Potent and highly selective ROCK inhibitor; orally active

AS 2444697

Potent and selective IRAK4 inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ASN 2016

ASN 2016

March 19 - 23, 2016

Denver, CO, USA