R&D Systems Inc. Tocris Bioscience Boston Biochem

ZIP

Cat. No. 2549

ZIP Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu

Price and Availability

For ZIP pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: z-Pseudosubstrate inhibitory peptide

Biological Activity

Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Control and biotinylated peptides (Cat. Nos. 3215 and 3290) also available.

Technical Data

M.Wt:
1928.4
Formula:
C90H154N30O17
Sequence:
SIYRRGARRWRKL

(Modifications: Ser-1 = Myr-Ser)

Solubility:
Soluble to 1 mg/ml in 20% ethanol / water
Storage:
Desiccate at -20°C
CAS No:
863987-12-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295.

Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979. PMID: 15728837.

Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141. PMID: 16931766.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: ZIP, supplier, Cell-permeable, inhibitors, atypical, PKC, isozyme, PKMzeta, Protein, Kinases, C

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Pain Research Product Guide

Pain Research Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Calcium Imbalance and Neuroprotective Targets

Written by E. Besancon et al

Neuroprotection Poster

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

PS 1145 dihydrochloride

Selective IKK inhibitor; orally active

RSVA 405

AMPK activator

Atiprimod dihydrochloride

JAK2 Inhibitor

AIM 100

Potent and selective Ack1 inhibitor

ML 120B dihydrochloride

Novel IKK2-selective inhibitor

ML 202

Pyruvate kinase M2 activator

GNF 5

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

TC-S 7005

Potent and selective PLK2 inhibitor

SRPIN340

Selective SRPK1 inhibitor

TC-S 7003

Potent Lck inhibitor

ML 281

STK33 inhibitor

CRT 0066101

Potent protein kinase D (PKD) inhibitor

Harmine

Potent and selective Dyrk1A inhibitor

AZ 628

Potent Raf kinase inhibitor

CHIR 99021 trihydrochloride

Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor

YZ9

PFKFB3 inhibitor; inhibits cell growth

KU 0060648

Dual DNA-PK and PI 3-K inhibitor

KB SRC 4

Potent and selective c-Src inhibitor

Sign-up for new product e-alerts
divider line

Tocris Events

Win $1,000 Product Credit

Experimental Biology

Experimental Biology

April 26 - 30, 2014

San Diego CA, USA

Booth Number: 918