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ZIP

Cat. No. 2549

ZIP Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu

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Alternative Name: z-Pseudosubstrate inhibitory peptide

Biological Activity

Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC₅₀ = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Control and biotinylated peptides (Cat. Nos. 3215 and 3290) also available.

Technical Data

M.Wt:

1928.4

Formula:

C₉₀H₁₅₄N₃₀O₁₇

Sequence:

SIYRRGARRWRKL

(Modifications: Ser-1 = Myr-Ser)

Solubility:

Soluble to 2 mg/ml in 30% acetonitrile / water

Storage:

Desiccate at -20°C

CAS No:

863987-12-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295.

Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979. PMID: 15728837.

Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141. PMID: 16931766.

If you know of a relevant citation for this product please let us know.

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