Cat. No. 2549
Alternative Name: z-Pseudosubstrate inhibitory peptide
Biological ActivityNovel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Control and biotinylated peptides (Cat. Nos. 3215 and 3290) also available.
(Modifications: Ser-1 = Myr-Ser)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295.
Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979. PMID: 15728837.
Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141. PMID: 16931766.
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Keywords: ZIP, supplier, Cell-permeable, inhibitors, atypical, PKC, isozyme, PKMzeta, Protein, Kinases, C
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