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NF 110

Cat. No. 2548

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Chemical Name: 4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonic acid tetrasodium salt

Biological Activity

High affinity P2X₃ receptor antagonist (K_i values are 36, 82 and 4144 nM for P2X₃, P2X₁ and P2X₂ recombinant receptors respectively). Shows no activity at P2Y₁, P2Y₂ and P2Y₁₁ receptors (IC₅₀ > 10 μM). Potently inhibits α,β-meATP-evoked desensitizing currents in rat DRG neurons (IC₅₀ = 527 nM). Shows antitumor activity against several tumor types.

Technical Data

M.Wt:

1096.9

Formula:

C₄₁H₂₈N₆Na₄O₁₇S₄

Solubility:

Soluble to 40 mM in water

Storage:

Desiccate at RT

CAS No:

111150-22-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Dhar et al (2000) Antitumour activity of suramin analogues in human tumour cell lines and primary cultures of tumour cells from patients. Eur.J.Cancer 36 803. PMID: 10762755.

Kassack et al (2004) Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X₁ receptor antagonist. Eur.J.Med.Chem. 39 345. PMID: 15072843.

Hausmann et al (2006) The suramin analog 4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X₃ receptors: subtype selectivity is determined by location of sulfonic acid groups. Mol.Pharmacol. 69 2058. PMID: 16551782.

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