R&D Systems Inc. Tocris Bioscience Boston Biochem

PKI 14-22 amide, myristoylated

Cat. No. 2546

PKI 14-22 amide, myristoylated Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

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Alternative Name: Protein kinase inhibitor-(14-22)-amide, myristoylated

Biological Activity

Cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).

Technical Data

M.Wt:
1209.5
Formula:
C53H100N20O12
Sequence:
GRTGRRNAI

(Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 30% acetonitrile
Storage:
Desiccate at -20°C
CAS No:
201422-03-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802. PMID: 2722799.

Zheng et al (2000) Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 275 31747. PMID: 10829013.

Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197. PMID: 12947318.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: PKI 14-22 amide, myristoylated, supplier, Cell-permeable, protein, kinases, A, inhibitors, Cell, permeable, PKA, PKI14-22, amide, myristoylated

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