PKI 14-22 amide, myristoylated

Cat. No. 2546

PKI 14-22 amide, myristoylated Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

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Alternative Name: Protein kinase inhibitor-(14-22)-amide, myristoylated

Biological Activity

Cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).

Technical Data


(Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)

Soluble to 1 mg/ml in 30% acetonitrile / water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet


Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802. PMID: 2722799.

Zheng et al (2000) Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 275 31747. PMID: 10829013.

Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197. PMID: 12947318.

If you know of a relevant citation for this product please let us know.

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Keywords: PKI 14-22 amide, myristoylated, supplier, Cell-permeable, protein, kinases, A, inhibitors, Cell, permeable, PKA, PKI14-22, amide, myristoylated, Protein Kinase A Inhibitors

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