PKI 14-22 amide, myristoylated
Cat. No. 2546
Alternative Name: Protein kinase inhibitor-(14-22)-amide, myristoylated
Biological ActivityCell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).
(Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802. PMID: 2722799.
Zheng et al (2000) Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 275 31747. PMID: 10829013.
Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197. PMID: 12947318.
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Keywords: PKI 14-22 amide, myristoylated, supplier, Cell-permeable, protein, kinases, A, inhibitors, Cell, permeable, PKA, PKI14-22, amide, myristoylated
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