PKI 14-22 amide, myristoylated
Cat. No. 2546
Alternative Name: Protein kinase inhibitor-(14-22)-amide, myristoylated
Biological ActivityCell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).
(Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802. PMID: 2722799.
Zheng et al (2000) Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 275 31747. PMID: 10829013.
Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197. PMID: 12947318.
If you know of a relevant citation for this product please let us know.
Keywords: PKI 14-22 amide, myristoylated, supplier, Cell-permeable, protein, kinases, A, inhibitors, Cell, permeable, PKA, PKI14-22, amide, myristoylated
Find multiple products by catalog number
New Products in this Area
Selective PFKFB3 inhibitorPD 0332991 isethionate
Potent, selective Cdk4/6 inhibitor; brain penetrantXL 413 hydrochloride
Potent and selective Cdc7 inhibitorC16
PKR inhibitorRp-8-pCPT-cGMPS sodium
PKG inhibitorTC-S 7004
Potent and selective DYRK1A/B inhibitorTAK 960 hydrochloride
Potent and selective PLK1 inhibitorA12B4C3
Potent and selective polynucleotide kinase/phosphatase (PKNP) inhibitorBMS 345541
Selective allosteric inhibitor of IKK; anti-inflammatoryWH-4-023
Potent and selective Lck and Src inhibitor; also inhibits SIKTC-S 7006
Potent and selective Tpl2 (Cot; MAP3K8) inhibitorOXA 06 dihydrochloride
Potent ROCK inhibitorPCI 29732
Potent BTK inhibitorMps1-IN-1 dihydrochloride
Selective monopolar spindle 1 (Mps1) kinase inhibitorCKI 7 dihydrochloride
CK1 inhibitorT 5601640
Selective LIMK2 inhibitor; antitumor3PO
PFKFB3 inhibitor; antiangiogenicCHR 6494 trifluoroacetate
Potent and selective haspin kinase inhibitorUNC 3230
Potent and selective PIP5K1C inhibitor; antinociceptivetrans-ISRIB
Integrated stress response (ISR) inhibitorBMS 509744
Potent and selective ITK inhibitor
September 5 - 8, 2015