R&D Systems Inc. Tocris Bioscience Boston Biochem

IKK 16

Cat. No. 2539

IKK 16 C28H29N5OS.HCl [1186195-62-9]

Price and Availability

For IKK 16 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride

Biological Activity

Selective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC50 values are 1.0, 0.5, 0.3 and 0.3 μM respectively). Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

Technical Data

M.Wt:
520.09
Formula:
C28H29N5OS.HCl
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
1186195-62-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Waelchli et al (2006) Design and preparation of 2-benzoamido-pyrimidines as inhibitors of IKK. Bioorg.Med.Chem.Lett. 16 108. PMID: 16236504.

If you know of a relevant citation for this product please let us know.

Keywords: IKK 16, supplier, Selective, inhibitors, IKK, IκB, IkappaB, Kinases, NF-κB, NF-kappaB, NF-kB, Transcription, Factors, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, IKK16

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Immunology Guide

Immunology Research Guide

Highlights over 150 products for immunology research. Request a copy or view PDF today.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

LIMKi 3

Potent LIM kinase inhibitor; antitumor

FRAX 486

Potent p21-activated kinase (PAK) inhibitor; brain penetrant and orally bioavailable

BIX 02189

Selective MEK5 and ERK5 inhibitor

TC Mps1 12

Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor; orally active

GSK 2606414

Potent and selective PERK inhibitor; orally bioavailable

AZ 20

Potent and selective ATR kinase inhibitor; antitumor

AZD 7762 hydrochloride

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2

PHT 427

Dual Akt and PDK1 inhibitor; antitumor

ML 786 dihydrochloride

Potent Raf kinase inhibitor; orally bioavailable

Senexin A

Cyclin-dependent kinase 8 (cdk8) inhibitor

XL 388

Potent and selective mTOR inhibitor; antitumor

PS 1145 dihydrochloride

Selective IKK inhibitor; orally active

RSVA 405

AMPK activator

Atiprimod dihydrochloride

JAK2 inhibitor

AIM 100

Potent and selective Ack1 inhibitor

ML 120B dihydrochloride

Novel IKK2-selective inhibitor

ML 202

Pyruvate kinase M2 activator

GNF 5

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

TC-S 7005

Potent and selective PLK2 inhibitor

SRPIN340

Selective SRPK1 inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Purines 2014

Purines 2014

July 23 - 27, 2014

Bonn University, Germany