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Anisomycin

Cat. No. 1290

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Chemical Name: (2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate

Biological Activity

Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).

Technical Data

M.Wt:

265.31

Formula:

C₁₄H₁₉NO₄

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

22862-76-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Cano et al (1994) Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun. Mol.Cell.Biol. 14 7352. PMID: 7935449.

Kyriakis et al (1994) The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369 156. PMID: 8177321.

Sanchez et al (1994) Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372 794. PMID: 7997269.

Hazzalin et al (1998) Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction. Mol.Cell.Biol. 18 1844. PMID: 9528756.

Croons et al (2009) The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase. J.Pharmacol.Exp.Ther. 329 856. PMID: 19286921.

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Keywords: Anisomycin, supplier, Protein, synthesis, inhibitors, blocks, blocker, translation, activates, Activator, JNK, stress-activated, SAPK, p38, MAP, protein, kinases, MAPK, Signaling, Signalling, c-Jun, N-Terminal, Kinase, Mitogen-Activated, antibiotics

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