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Ganaxolone

Cat No. 2531

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Alternative Name: CCD 1042

Chemical Name: (3a,5a)-3-Hydroxy-3-methyl-pregnan-20-one

Biological Activity

Potent positive allosteric modulator of GABA_A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA_A receptors (EC₅₀ values are 94, 122 and 213 nM for α2β1γ2_L, α3β1γ2_L and α1β1γ2_L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.

Technical Data

M.Wt:

332.53

Formula:

C₂₂H₃₆O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Storage:

Store at +4°C

CAS No:

[38398-32-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Carter et al (1997) Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3a-hydroxy-3b-methyl-5a-pregnan-20-one), a selective, high affinity, steroid modulator of the g-aminobutyric acid_A receptor. J.Pharmacol.Exp.Ther. 280 1284. Lyden et al (2000) Effect of ganaxolone in a rodent model of cerebral hematoma. Stroke 31 169. Ungard et al (2000) Modification of behavioral effects of drugs in mice by neuroactive steroids. Psychopharmacology 148 336.

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