PD 166793

Cat. No. 2520

PD 166793 C17H18BrNO4S [199850-67-4]

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Chemical Name: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine

Biological Activity

Broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

Technical Data

M.Wt:
412.3
Formula:
C17H18BrNO4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
199850-67-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

O'Brien et al (2000) Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available Biphenylsulfonamide matrix metalloproteinase inhibitors. J.Med.Chem. 43 156. PMID: 10649971.

Peterson et al (2001) Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Circulation 103 2303. PMID: 11342481.

Chancey et al (2002) Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation 105 1983. PMID: 11997287.

If you know of a relevant citation for this product please let us know.

Keywords: PD 166793, supplier, Broad, spectrum, MMP, inhibitors, Matrixins, Matrix, Metalloproteinase, Metalloprotease, Proteinases, Proteases, PD166793

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