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PD 166793

Cat. No. 2520

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Chemical Name: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine

Biological Activity

Broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC₅₀ values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

Technical Data

M.Wt:

412.3

Formula:

C₁₇H₁₈BrNO₄S

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

199850-67-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

O'Brien et al (2000) Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available Biphenylsulfonamide matrix metalloproteinase inhibitors. J.Med.Chem. 43 156. PMID: 10649971.

Peterson et al (2001) Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Circulation 103 2303. PMID: 11342481.

Chancey et al (2002) Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation 105 1983. PMID: 11997287.

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