Cat. No. 2520
Chemical Name: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine
Biological ActivityBroad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
O'Brien et al (2000) Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available Biphenylsulfonamide matrix metalloproteinase inhibitors. J.Med.Chem. 43 156. PMID: 10649971.
Peterson et al (2001) Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Circulation 103 2303. PMID: 11342481.
Chancey et al (2002) Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation 105 1983. PMID: 11997287.
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Keywords: PD 166793, supplier, Broad, spectrum, MMP, inhibitors, Matrixins, Matrix, Metalloproteinase, Metalloprotease, Proteinases, Proteases, PD166793
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