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APC 366

Cat. No. 2511

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Chemical Name: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide

Biological Activity

Selective inhibitor of mast cell tryptase (K_i = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo.

Technical Data

M.Wt:

440.5

Formula:

C₂₂H₂₈N₆O₄

Sequence:

N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide

Solubility:

Soluble to 1 mg/ml in 20% acetonitrile

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

178925-65-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Numerof et al (1997) Tryptase inhibitors: a novel class of anti-inflammatory drugs. Exp.Opin.Invest.Drugs. 6 811.

Barrios et al (1998) Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 63 2295. PMID: 9877219.

He et al (1998) A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase. J.Pharmacol.Exp.Ther. 286 289. PMID: 9655871.

He et al (2004) Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J.Pharmacol.Exp.Ther. 309 119. PMID: 14722328.

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