Cat. No. 2506
Chemical Name: 2-[[6-Methoxy-4-(1-methylethyl)-1,1
Biological ActivityHigh affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Bidouard et al (2003) SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury. Eur.J.Pharmacol. 461 49. PMID: 12568915.
Kapui et al (2003) Biochemical and pharmacological characterization of 2-(9-(2-Piperidinoethoxy)-4-oxo-4H-pyrido[1,2-α]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor. J.Pharmacol.Exp.Ther. 305 451. PMID: 12606659.
Varga et al (2003) A novel orally active inhibitor of HLE. Eur.J.Med.Chem. 38 421. PMID: 12750030.
If you know of a relevant citation for this product please let us know.
Keywords: SSR 69071, supplier, Potent, orally, active, human, leukocyte, elastase, inhibitors, Neutrophil, Proteinases, Proteases, SSR69071, HLE, inhibitor
Find multiple products by catalog number
New Products in this Area
Dipeptidyl peptidase II (DPP-II) inhibitorVialinin A
Inhibitor of USP4 and USP5/IsoTMI 2 (MALT1 inhibitor)
MALT1 inhibitorNSC 687852
Inhibitor UCHL5 and USP14
Win a Kindle Fire HD
April 26 - 30, 2014
San Diego CA, USA
Booth Number: 918